Research Use Only
This page is intended for educational and research purposes only. Apex Chem Labs products are not intended for human or animal use.
Summary
IGF-1 LR3 is a modified version of IGF-1, a growth factor involved in cell growth, survival, and repair-related signaling. The “LR3” version is designed differently from regular IGF-1 so it interacts less with IGF-binding proteins, which are proteins that normally limit IGF-1 activity. In simple terms, researchers study IGF-1 LR3 because it is built to stay more available in research systems and strongly interact with IGF-1 receptor pathways involved in growth-factor signaling.
Overview
IGF-1 LR3, also known as Long R3 Insulin-like Growth Factor-1 or Long Arg3 IGF-1, is an engineered analog of human IGF-1. It contains the complete IGF-1 sequence with an arginine substitution at position three and an additional 13-amino-acid extension at the N-terminus, giving it a total length of 83 amino acids. These structural changes are associated with reduced affinity for IGF-binding proteins and increased bioavailability in experimental systems.
Research Background
IGF-1 is a naturally occurring growth factor involved in cellular growth, proliferation, differentiation, survival, and metabolism-related signaling. IGF-1 LR3 was developed as a modified analog with reduced binding to IGF-binding proteins, which can inhibit or regulate native IGF-1 activity. Because of these differences, IGF-1 LR3 is frequently studied in cell culture, growth-factor signaling, receptor activation, tissue models, and recombinant protein production systems.
Mechanisms Studied
Research interest around IGF-1 LR3 focuses mainly on IGF-1 receptor signaling and downstream pathways involved in cell survival, proliferation, and growth-related activity. IGF-1 receptor activation is commonly associated with signaling networks such as PI3K/Akt and MAPK/ERK pathways. In cell culture research, IGF-1 LR3 is studied as a growth and survival factor, especially in systems where reduced interaction with IGF-binding proteins may increase available receptor activity.
Published Research Summary
Research literature describes IGF-1 LR3 as a potent IGF-1 analog with reduced affinity for IGF-binding proteins. Studies have evaluated Long R3 IGF-1 in cell culture systems, recombinant expression systems, animal models, and neurological disease research models. One study reported that Long R3 IGF-1 acted as a more potent growth and survival factor than either insulin or native IGF-1 in serum-free HEK293 cell culture. Other research has investigated Long R3 IGF-1 in relation to organ growth models, bowel mass/function models, and Alzheimer’s disease mouse models. Overall, IGF-1 LR3 is best understood as a modified research analog used to study IGF-1 receptor signaling and growth-factor biology.
Quality & Verification
For research compounds such as IGF-1 LR3, documentation is important. Researchers commonly review batch-specific Certificates of Analysis, HPLC purity data, mass spectrometry verification, lot identification, and molecular identity testing to evaluate analytical quality and consistency.
References & Published Research
- Insulin-Like Growth Factor-1 (IGF-1) and Its Monitoring in Medical and Sports Contexts
- Intranasal Long R3 Insulin-Like Growth Factor-1 Treatment in an Alzheimer’s Disease Mouse Model
- Recombinant Expression of IGF-1 and LR3 IGF-1 in Pichia pastoris
- LONG R3 IGF-I as a More Potent Alternative to Insulin in Serum-Free Culture of HEK293 Cells
- Long R3 Insulin-Like Growth Factor-I Infusion and Organ Growth Research
- Effects of IGF-I and Long R3 IGF-I in Intestinal Research Models